Toxicity of CSF in motor neurone disease: a potential route to neuroprotection
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چکیده
منابع مشابه
Toxicity of CSF in motor neurone disease: a potential route to neuroprotection.
reports that CSF from patients with motor neurone disease (MND) is toxic to cultured spinal cord neurones and that the tetracycline antibiotic minocycline exerts a signi®cant neuro-protective effect against this toxicity (Tikka et al., 2002). There is a tendency in MND for the disease to start focally, for example with weakness of one hand, unilateral foot drop or dysarthria. As judged by clini...
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Motor neurone disease (MND), or amyotrophic lateral sclerosis (ALS), is a neurodegenerative disorder of unknown aetiology. Progressive motor weakness and bulbar dysfunction lead to premature death, usually from respiratory failure. Confirming the diagnosis may initially be difficult until the full clinical features are manifest. For all forms of the disease there is a significant differential d...
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ژورنال
عنوان ژورنال: Brain
سال: 2002
ISSN: 1460-2156,0006-8950
DOI: 10.1093/brain/awf138